Mucosal barriers are densely colonized by pathobiont microbes such as Candida albicans,
capable of invasive disseminated infection. However, systemic infections occur infrequently�…

Th17 cells provide protection at barrier tissues but may also contribute to immune pathology.
The relevance and induction mechanisms of pathologic Th17 responses in humans are�…

Candida albicans causes mucosal and disseminated candidiasis, which represent serious
problems for the rapidly expanding immunocompromised population. Until recently, Th1�…

Our understanding of immunity to fungal pathogens has advanced considerably in recent
years. Particularly significant have been the parallel discoveries in the C-type lectin receptor�…

The host immune status is critical for preventing opportunistic infections with Candida
albicans. Whether the natural fungal diversity that exists between C. albicans isolates also�…

The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush)
in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all�…

Oropharyngeal candidiasis (OPC) is an opportunistic infection caused by Candida albicans.
Despite its prevalence, little is known about C. albicans-specific immunity in the oral�…

Interactions between mucosal surfaces and microbial microbiota are key to host defense,
health, and disease. These surfaces are exposed to high numbers of microbes and must be�…

IL-17 is one of the key cytokines that stimulate host defense during a Candida infection.
Several studies have demonstrated the capacity of Candida albicans to induce a Th17�…

Keeping a stable equilibrium between the host and commensal microbes to which we are
constantly exposed, poses a major challenge for the immune system. The host mechanisms�…