Dietary fiber protects against chronic inflammatory diseases by dampening immune
responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary�…

Innate lymphoid cells (ILCs) rapidly undergo expansion in population size and functional
maturation in response to cytokines that signal infection, tissue damage, or changes in�…

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and,
consequently, the health or disease of the intestinal tract. However, whether such host�…

Trained immunity is an innate immune memory response that is induced by a primary
inflammatory stimulus that sensitizes monocytes and macrophages to a secondary�…

A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered�…

Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation.
However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short�…

The mammalian gastrointestinal tract harbors a microbial community with metabolic activity
critical for host health, including metabolites that can modulate effector functions of immune�…

A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role�…

Dietary fiber intake in humans is nowadays substantially decreased as compared to the
communities of ancestral populations. Accompanying that, the incidences of inflammatory�…

T cells are central players in the regulation of adaptive immunity and immune tolerance. In
the periphery, T cell differentiation for maturation and effector function is regulated by a�…