Background Both genetic and lifestyle factors contribute to individual-level risk of coronary
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle�…

Purpose: Because multiple genetic variants influence risk for coronary heart disease, we
combined multiple variants that had been associated with coronary heart disease in several�…

Importance Genetic and lifestyle factors both contribute to the risk of developing
cardiovascular disease, but whether poor health behaviors are associated with similar�…

Background: Understanding the effect of lifestyle and genetic risk on the lifetime risk of
coronary heart disease (CHD) is important to improving public health initiatives. Our�…

Context While multiple genetic markers associated with cardiovascular disease have been
identified by genome-wide association studies, their aggregate effect on risk beyond�…

Importance Familial hypercholesterolemia variants impair clearance of cholesterol from the
circulation and increase risk of coronary artery disease (CAD). The extent to which�…

Coronary artery disease (CAD) is a pandemic disease that is highly preventable as shown
by secondary prevention. Primary prevention is preferred knowing that 50% of the�…

Background: Family history is an important cardiovascular disease (CVD) risk factor.
Preventive behaviors, including lifestyle modifications, can attenuate CVD risk. We studied�…

Background—Whether knowledge of genetic risk for coronary heart disease (CHD) affects
health-related outcomes is unknown. We investigated whether incorporating a genetic risk�…

Importance The clinical utility of polygenic risk scores (PRS) for coronary artery disease
(CAD) has not yet been established. Objective To investigate the ability of a CAD PRS to�…