Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue�…

Macrophages have protective roles in immunity to pathogens, tissue development,
homeostasis and repair following damage. Maladaptive immunity and inflammation provoke�…

Macrophages are essential components of mammalian tissues. Although historically known
mainly for their function in host defense and the clearance of apoptotic cells, macrophages�…

Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages�…

The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural�…

Over the past decade, modern genetic tools have permitted scientists to study the function of
myeloid lineage cells, including macrophages, as never before. Macrophages were first�…

Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste�…

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life,
constituting a widely dispersed organ system. They promote homeostasis by responding to�…

Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and
immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive�…

Macrophages provide a critical systemic network cells of the innate immune system.
Emerging data suggest that in addition, they have important tissue-specific functions that�…