[HTML][HTML] ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang…�- Nature�…, 2020 - nature.com
The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the�…
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the�…
[HTML][HTML] Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global
health issue. Mechanisms implicated in virus/host cells interaction are central for cell�…
health issue. Mechanisms implicated in virus/host cells interaction are central for cell�…
Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium
H Zhang, MR Rostami, PL Leopold…�- American journal of�…, 2020 - atsjournals.org
Rationale: Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) causes coronavirus disease (COVID-19), a predominantly respiratory illness. The first�…
2) causes coronavirus disease (COVID-19), a predominantly respiratory illness. The first�…
[HTML][HTML] A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
Abstract Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial
cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion�…
cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion�…
[HTML][HTML] ACE2, much more than just a receptor for SARS-COV-2
L Samavati, BD Uhal�- Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-
CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2)�…
CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2)�…
Lung expression of human angiotensin-converting enzyme 2 sensitizes the mouse to SARS-CoV-2 infection
Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human�…
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human�…
[HTML][HTML] ACE2: the major cell entry receptor for SARS-CoV-2
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred�…
has infected more than 46 million people worldwide, killing over one million two hundred�…
[HTML][HTML] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS�…
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS�…
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S)
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular�…
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular�…
[HTML][HTML] Novel sars-cov-2 receptors: asgr1 and kremen1
M Hoffmann, S P�hlmann�- Cell research, 2022 - nature.com
The interaction of the SARS-CoV-2 spike protein with the cellular receptor ACE2 is believed
to be essential for viral entry into host cells. In a recent paper published in Cell Research, Gu�…
to be essential for viral entry into host cells. In a recent paper published in Cell Research, Gu�…
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