[HTML][HTML] Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission

K Tokudome, T Okumura, S Shimizu, T Mashimo…�- Scientific reports, 2016 - nature.com
Synaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating
action potential-dependent neurotransmitters release. SV2A also serves as a specific�…

[HTML][HTML] A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA�…

K Tokudome, T Okumura, R Terada…�- Frontiers in�…, 2016 - frontiersin.org
Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of
synaptic vesicles and modulates action potential-dependent neurotransmitter release. To�…

Therapeutic role of synaptic vesicle glycoprotein 2A (SV2A) in modulating epileptogenesis

Y Ohno, K Tokudome�- …�(Formerly Current Drug Targets-CNS &�…, 2017 - ingentaconnect.com
Dysfunction of synaptic neurotransmitter release is closely involved in the pathogenesis of
various central nervous system diseases. Synaptic vesicle glycoprotein 2A (SV2A) is a�…

[HTML][HTML] Targeting SV2A for discovery of antiepileptic drugs

RM Kaminski, M Gillard, H Klitgaard - 2012 - europepmc.org
Levetiracetam's (Keppra�) binding site and its subsequent identification as the synaptic
vesicle protein 2A (SV2A) has opened a new and successful avenue for drug discovery�…

Differential expression of synaptic vesicle protein 2A after status epilepticus and during epilepsy in a lithium-pilocarpine model

IJ Contreras-Garc�a, LA Pichardo-Mac�as…�- Epilepsy & Behavior, 2018 - Elsevier
Synaptic vesicle protein 2A (SV2A) has become an attractive target of investigation because
of its role in the pathophysiology of epilepsy; SV2A is expressed ubiquitously throughout the�…

An epilepsy-associated SV2A mutation disrupts synaptotagmin-1 expression and activity-dependent trafficking

CB Harper, C Small, EC Davenport…�- Journal of�…, 2020 - Soc Neuroscience
The epilepsy-linked gene SV2A, has a number of potential roles in the synaptic vesicle (SV)
life cycle. However, how loss of SV2A function translates into presynaptic dysfunction and�…

[HTML][HTML] Puzzling out synaptic vesicle 2 family members functions

O Bartholome, P Van den Ackerveken…�- Frontiers in molecular�…, 2017 - frontiersin.org
Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear
demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam�…

Down-regulation synaptic vesicle protein 2A in the anterior temporal neocortex of patients with intractable epilepsy

G Feng, F Xiao, Y Lu, Z Huang, J Yuan, Z Xiao…�- Journal of molecular�…, 2009 - Springer
Synaptic vesicle protein 2A (SV2A) involvement has been reported in the animal models of
epilepsy. The aim of this study was to investigate the expression of SV2A in human�…

[HTML][HTML] Expression of SV2 isoforms during rodent brain development

J Cr�vecœur, P Foerch, M Doupagne, C Thielen…�- BMC neuroscience, 2013 - Springer
Abstract Background SV2A, SV2B and SV2C are synaptic vesicle proteins that are
structurally related to members of the major facilitator superfamily (MFS). The function and�…

[HTML][HTML] Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)

BA Pazarlar, SS Aripaka, V Petukhov, L Pinborg…�- Molecular brain, 2022 - Springer
Abstract Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A,
SV2B, and SV2C. This protein family has attracted attention in recent years after SV2A was�…