The purpose of this study was to quantify the various sources of estrone (E1) and 17β-
estradiol (E2) production in normal men and in women with testicular feminization. The�…

The secretion of androgens and estrogens by normal and abnormal testes was compared by
determining the concentrations of dehydroepiandrosterone (DHEA), androstenedione (Δ4A)�…

The role of the human testis in the production of 17β-estradiol (E2) was investigated by
determining the concentration of E2 and testosterone in peripheral and spermatic vein�…

Continuous infusions of Δ4-androstenedione-7-3H and testosterone-7-3H have been used
to demonstrate that these androgens are converted to estrone and 17β-estradiol, and�…

To determine the intratesticular site of aromatization, homogenates of separated
seminiferous tubules and intact tissue from human testes were incubated with [3H]�…

After the intravenous administration of tracer doses of 4-14C-Δ4-androstenedione+ 6, 7-3H-
estrone (or 6, 7-3H-estradiol) to normal adult males, and normal, castrate and�…

The effect of estradiol-17β on the conversion of 3H-dehydroepiandrosterone (DHA) in
human testicular tissue was studied in 24-hr organ culture. With the addition of increasing�…

C HORIONIC gonadotropin is known to stimulate growth and endocrine function of the
immature human testis. When administered to cryptorchid boys, it can produce enlargement�…

To explain certain clinical observations, such as feminization in pubescent boys and men
with testicular tumors, it has been suggested that androgens may be metabolized to�…

Role of 2-Hydroxyestrone in Estrogen Metabolism JACK FISHMAN, PH.D. Page 1 Role of 2-Hydroxyestrone
in Estrogen Metabolism JACK FISHMAN, PH.D. Sloan-Kettering Institute for Cancer�…