Abstract GLIOBLASTOMA IS THE most malignant primary brain tumor. Inhibition of
angiogenesis is one potential strategy for treating this fatal hypervascular tumor. AGM-1470�…

Angiogenesis is a process fundamental to the growth of many solid tumours. Agents that
inhibit angiogenesis may have a role in preventing tumour growth. AGM-1470, a synthetic�…

A novel angiogenesis inhibitor TNP-470 was investigated for its anti-tumor activity against
malignant gliomas both in vitro and in vivo. TNP-470 cytostatically inhibited the growth in all�…

✓ The effectiveness of AGM-1470, a potent, fungal-derived inhibitor of angiogenesis, in
suppressing the neovascularization and growth of human Schwann cell tumors was tested�…

The effect of the anti-angiogenic agent TNP-470 on tumor growth, vascular area, vascular
density and tumor perfusion of two different subcutaneously implanted human glioma�…

The effect of the potent angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-
470), a semisynthetic analogue of fumagillin, on tumor growth and metastasis was studied�…

Using the rat tumour cell line LY80, a subline of Yoshida sarcoma, the effects of AGM-1470
on the growth of primary tumour and the incidence of regional lymph node metastasis were�…

AGM-1470 is a potent angiogenesis inhibitor that is very effective in inhibiting endothelial
cell proliferation in both in vitro and in vivo models and that prevents tumor growth in vivo�…

Anti-angiogenic agents were be clinically useful for the therapy of solid tumors, as the
growth and proliferation of tumors require neovascularization. Previous reports have been�…

Angiogenesis is a fundamental process by which new blood vessels are formed.
Progressive tumor growth necessitates the continuous induction of new capillary blood�…