Damaged bases in DNA are known to lead to errors in replication and transcription,
compromising the integrity of the genome. We have proposed a model where repair proteins�…

The stacked aromatic base pairs within the DNA double helix facilitate charge transport
down its length in the absence of lesions, mismatches, and other stacking perturbations�…

Base excision repair (BER) enzymes maintain the integrity of the genome, and in humans,
BER mutations are associated with cancer. Given the remarkable sensitivity of DNA�…

Endonuclease III (EndoIII) is a base excision repair glycosylase that targets damaged
pyrimidines and contains a [4Fe-4S] cluster. We have proposed a model where BER�…

The unique characteristics of DNA charge transport (CT) have prompted an examination of
roles for this chemistry within a biological context. Not only can DNA CT facilitate long-range�…

A central question important to understanding DNA repair is how certain proteins are able to
search for, detect, and fix DNA damage on a biologically relevant time scale. A feature of�…

Iron–sulfur clusters have increasingly been found to be associated with enzymes involved in
DNA processing. Here we describe a role for these redox clusters in DNA-mediated charge�…

The DNA duplex is an exquisite macromolecular array that stores genetic information to
encode proteins and regulate pathways. Its unique structure also imparts chemical function�…

Many DNA-processing enzymes have been shown to contain a [4Fe4S] cluster, a common
redox cofactor in biology. Using DNA electrochemistry, we find that binding of the DNA�…

Escherichia coli endonuclease III (EndoIII) and MutY are DNA glycosylases that contain
[4Fe4S] clusters and that serve to maintain the integrity of the genome after oxidative stress�…