Extracellular ATP serves as a danger signal to alert the immune system of tissue damage by
acting on P2X or P2Y receptors. Here we show that allergen challenge causes acute�…

Barrier epithelial cells and airway dendritic cells (DCs) make up the first line of defense
against inhaled substances such as house dust mite (HDM) allergen and endotoxin�…

Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity�…

Extracellular ATP acts as a “danger signal” and can induce inflammation by binding to
purinergic receptors. Chronic obstructive pulmonary disease is one of the most common�…

The molecular mechanisms underlying the initiation of innate and adaptive proallergic Th2-
type responses in the airways are not well understood. IL-33 is a new member of the IL-1�…

Extracellular ATP is a signalling molecule that often serves as a danger signal to alert the
immune system of tissue damage. This molecule activates P2 nucleotide receptors, that�…

The recognition that asthma is primarily an inflammatory disorder of the airways associated
with T helper type 2 (TH2) cell-dependent promotion of IgE production and recruitment of�…

Lung dendritic cells bridge innate and adaptive immunity, integrating a variety of stimuli from
allergens, microbial colonisation, environmental pollution, and innate immune cells into a�…

To cite this article: M�ller T, Robaye B, Vieira RP, Ferrari D, Grimm M, Jakob T, Martin SF, Di
Virgilio F, Boeynaems J‐M, Virchow JC, Idzko M. The purinergic receptor P2Y2 receptor�…

Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly�…