By virtue of their location within blood vessels and their ability to express foreign genes,
endothelial cells are attractive vehicles for the delivery of therapeutic molecules in vivo. We�…

Tumor endothelial cells have long been regarded as genomically stable and therefore less
likely to develop resistance to antiangiogenic therapies. However, recent findings have�…

The delivery of therapeutic genes to primary brain neoplasms opens new opportunities for
treating these frequently fatal tumors. Efficient gene delivery to tissues remains an important�…

factor, we have performed experiments examining the expression and biologic function of
the recombinant human PDGF B gene in porcine peripheral arteries. The PDGF B gene has�…

Angiogenesis and post-natal vasculogenesis are two processes involved in the formation of
new vessels, and both are essential for tumour growth and metastases. We isolated�…

In this study, we attempted to assess the incorporable potential of vascular endothelial cells
derived from adult organ blood vessels into tumor blood vessels. Two kinds of adult organ�…

Human and mouse proliferation-competent, bone marrow or peripheral circulation derived
endothelial progenitor-like cells (EPCs) were isolated, expanded and genetically�…

To develop a cellular vehicle able to reach systemically disseminated areas of
angiogenesis, we sought to exploit the natural tropism of circulating endothelial progenitor�…

Based on the concept that solid tumors cannot grow without the generation of new blood
vessels, there is growing interest in the use of antiangiogenesis agents to inhibit tumor�…

The maintenance of tissues of virtually all organs depends on a sufficient blood supply.
During embryogenesis, primitive blood vessels are formed de novo by the aggregation of�…