Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

AJ McFarlane, HJ McSorley, DJ Davidson…�- Journal of Allergy and�…, 2017 - Elsevier
Background Helminth parasites have been reported to have beneficial immunomodulatory
effects in patients with allergic and autoimmune conditions and detrimental consequences in�…

[HTML][HTML] Host immunity and inflammation to pulmonary helminth infections

JE Weatherhead, P Gazzinelli-Guimaraes…�- Frontiers in�…, 2020 - frontiersin.org
Helminths, including nematodes, cestodes and trematodes, are complex parasitic organisms
that infect at least one billion people globally living in extreme poverty. Helminthic infections�…

Helminth induced immunoregulation and novel therapeutic avenue of allergy

B Ayelign, Y Akalu, B Teferi, MD Molla…�- Journal of asthma and�…, 2020 - Taylor & Francis
Allergic diseases are increasing at an alarming rate worldwide, particularly in developed
countries. In contrast, there is a decrease in the prevalence of helminthic infections and�…

[HTML][HTML] Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites

KJ Filbey, M Camberis, J Chandler, R Turner…�- Mucosal�…, 2019 - nature.com
The ability of helminths to manipulate the immune system of their hosts to ensure their own
survival is often credited with affecting responses to other pathogens. We undertook co�…

Critical roles of regulatory B and T cells in helminth parasite-induced protection against allergic airway inflammation

X Gao, X Ren, Q Wang, Z Yang, Y Li…�- Clinical & Experimental�…, 2019 - academic.oup.com
The prevalence of allergic asthma and incidences of helminth infections in humans are
inversely correlated. Although experimental studies have established the causal relation�…

Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection

HH Smits, H Hammad, M van Nimwegen…�- Journal of Allergy and�…, 2007 - Elsevier
BACKGROUND: Population studies have suggested that chronic and intense helminth
infections, in contrast to acute and mild helminth infections, might suppress allergic airway�…

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine�…

AM Dittrich, A Erbacher, S Specht, F Diesner…�- The journal of�…, 2008 - journals.aai.org
Numerous epidemiological studies have shown an inverse correlation between helminth
infections and the manifestation of atopic diseases, yet the immunological mechanisms�…

[HTML][HTML] The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation

MM Zaiss, A Rapin, L Lebon, LK Dubey, I Mosconi…�- Immunity, 2015 - cell.com
Intestinal helminths are potent regulators of their host's immune system and can ameliorate
inflammatory diseases such as allergic asthma. In the present study we have assessed�…

[HTML][HTML] Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development

PH Gazzinelli-Guimaraes…�- The Journal of�…, 2019 - Am Soc Clin Investig
This study investigates the relationship between helminth infection and allergic sensitization
by assessing the influence of preexisting allergy on the outcome of helminth infections�…

[HTML][HTML] Systemic impact of intestinal helminth infections

PK Mishra, M Palma, D Bleich, P Loke, WC Gause�- Mucosal immunology, 2014 - Elsevier
In this review, we examine the evidence that intestinal helminths can control harmful
inflammatory responses and promote homeostasis by triggering systemic immune�…