Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
The immunostimulatory cytokine interleukin-2 (IL-2) is a growth factor for a wide range of
leukocytes, including T cells and natural killer (NK) cells,,. Considerable effort has been�…
leukocytes, including T cells and natural killer (NK) cells,,. Considerable effort has been�…
Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines
IS Junttila, RJ Creusot, I Moraga, DL Bates…�- Nature chemical�…, 2012 - nature.com
Cytokines dimerize their receptors, with the binding of the'second chain'triggering signaling.
In the interleukin (IL)-4 and IL-13 system, different cell types express varying numbers of�…
In the interleukin (IL)-4 and IL-13 system, different cell types express varying numbers of�…
De novo design of potent and selective mimics of IL-2 and IL-15
We describe a de novo computational approach for designing proteins that recapitulate the
binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid�…
binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid�…
[HTML][HTML] Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps
Summary Interleukin-2 (IL-2) regulates lymphocyte function by signaling through
heterodimerization of the IL-2Rβ and γ c receptor subunits. IL-2 is of considerable�…
heterodimerization of the IL-2Rβ and γ c receptor subunits. IL-2 is of considerable�…
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
Adoptive transfer of antigen-specific T cells represents a major advance in cancer
immunotherapy, with robust clinical outcomes in some patients. Both the number of�…
immunotherapy, with robust clinical outcomes in some patients. Both the number of�…
[HTML][HTML] Potentiating adoptive cell therapy using synthetic IL-9 receptors
Synthetic receptor signalling has the potential to endow adoptively transferred T cells with
new functions that overcome major barriers in the treatment of solid tumours, including the�…
new functions that overcome major barriers in the treatment of solid tumours, including the�…
Structure-based decoupling of the pro-and anti-inflammatory functions of interleukin-10
RA Saxton, N Tsutsumi, LL Su, GC Abhiraman…�- Science, 2021 - science.org
INTRODUCTION Interleukin-10 (IL-10) is an important immunoregulatory cytokine that acts
to suppress and terminate inflammatory immune responses, largely through the inhibition of�…
to suppress and terminate inflammatory immune responses, largely through the inhibition of�…
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
H Schorle, T Holtschke, T H�nig, A Schimpl, I Horak�- Nature, 1991 - nature.com
Abstract INTERLEUKIN-2 (IL-2) is a lymphocytotropic hormone which is thought to have a
key role in the immune response of mammalian cells. It is produced by a subpopulation of�…
key role in the immune response of mammalian cells. It is produced by a subpopulation of�…
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation
K Ochiai, M Maienschein-Cline, M Mandal…�- Nature�…, 2012 - nature.com
The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the
B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated. Here we�…
B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated. Here we�…
Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression
Abstract T helper type 2 (TH2) cells are essential for humoral immunity and host defense.
Interleukin 4 (IL-4) drives TH2 differentiation and IL-2 augments the accessibility of Il4�…
Interleukin 4 (IL-4) drives TH2 differentiation and IL-2 augments the accessibility of Il4�…