The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular
metabolism with gene silencing and aging. The androgen receptor (AR) is a ligand�…

In prostate and breast cancer, the androgen and estrogen receptors mediate induction of
androgen-and estrogen-responsive genes respectively, and stimulate cell proliferation in�…

Androgen antagonists or androgen deprivation is a primary therapeutic modality for the
treatment of prostate cancer. Invariably, however, the disease becomes progressive and�…

Prostate cancer (PCa) is a major age-related malignancy, and according to estimates from
the American Cancer Society, a man's chance of developing this cancer significantly�…

In mammals, the Sirtuins are composed of seven Sir2 orthologs (Sirt1–7) with a conserved
deacetylase core that utilizes NAD+ as a cofactor. Interestingly, the deacetylase core of Sirt1�…

Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and�…

Estrogen receptor α (ERα) mediates estrogen-dependent gene transcription, which plays a
critical role in mammary gland development, reproduction and homeostasis. Histone�…

Human SIRT1 is an NAD+-dependent deacetylase protein that plays a role in cell
death/survival, senescence, and endocrine signaling. While its substrates, including p53�…

Prostate Cancer (PCa), next only to skin cancer, is the most commonly occurring malignancy
in men in the USA. Aging is recognized as a major risk factor for this neoplasm as a man's�…

Aging and cancer both occur as a result of accumulated cellular damage, and both are
related to the regulation of specific genes in the damage response. Recent research has�…