Over 40 years ago, Dieckmann and Michel reported that vascular reactivity to the pressor
effects of a vasoactive agent (crude vasopressin) is greater in preeclamptic than in�…

Human pregnancy is characterized by a blunted pressor responsiveness to vasopressor
substances. This was first reported by Dieckmann and Michel in 1937 in experiments in�…

The mechanism of decreased pressor responsiveness to pressor agents was examined
serially throughout pregnancy in conscious rats. Rats, 15 and 20 days pregnant, showed�…

FOR THE LAST several years, the pregnancy complication preeclampsia has been viewed
as more than simply pregnancy-induced hypertension. 1 The hypothesis that preeclampsia�…

Renal hemodynamics increase dramatically during pregnancy, and pressor responsiveness
to exogenous administration of vasoconstrictors is attenuated. We investigated whether or�…

Whether measured with Evans blue dye (57) or by radioactive labeling techniques (48, 54,
71, 73), changes in maternal plasma volume are detectable beginning early in pregnancy�…

The present study was designed to (1) outline, in a prospective manner, vascular
responsiveness to angiotensin II (A-II) in gravidas with essential hypertension and (2)�…

The present study was designed to ascertain sequentially the pressor response to
angiotensin II in young primigravid patients throughout pregnancy in order a) to define when�…

The purpose of this investigation was to study the determinants of the pressor response to
infused angiotensin II in normal pregnant women near term. In these subjects acute plasma�…

In gravid women who are destined to develop pregnancy-induced hypertension (PIH),
normal pregnancy-associated refractoriness to the pressor effects of administered�…