The purpose of the present study was to ascertain the relationship between aging and the
extent of conversion of plasma androstenedione to estrone. Studies were carried out in 23�…

After the intravenous administration of tracer doses of 4-14C-Δ4-androstenedione+ 6, 7-3H-
estrone (or 6, 7-3H-estradiol) to normal adult males, and normal, castrate and�…

The purpose of the present study was to investigate the mechanisms by which estrogen
production arises in the human female following the menopause. The possibilities�…

Urinary production rates of dehydroepiandrosterone (D) and dehydroepiandrosterone
sulfate (DS) by isotope dilution, and the blood production rate of androstenedione (A) by�…

Continuous infusions of Δ4-androstenedione-7-3H and testosterone-7-3H have been used
to demonstrate that these androgens are converted to estrone and 17β-estradiol, and�…

In postmenopausal women, the circulating levels of estrone (E 1) and estradiol (E 2) may be
of clinical importance. The origin of E 1, but not of E 2, has been defined. To examine the�…

Role of 2-Hydroxyestrone in Estrogen Metabolism JACK FISHMAN, PH.D. Page 1 Role of 2-Hydroxyestrone
in Estrogen Metabolism JACK FISHMAN, PH.D. Sloan-Kettering Institute for Cancer�…

This report describes the mechanism of origin and the quantity of estrogen produced in a
prepubertal boy who developed severe feminization at 8 yr of age as the result of a�…

The peripheral conversion of dehydroisoandrosterone (D) to plasma androstenedione (A)
and testosterone (T) was studied by constant infusion of labeled D and isolation of both�…

Methods Normal adults, aged 21 to 33, were used in these stud-ies. All female subjects gave
histories of normal and regular menstrual cycles, were in excellent general health, and�…