TLE Models and Comorbidities and thereby constituted a valid model of TLE showed mild to
no spatial performance impairment. Recently, the same group used identical protocols (PILO�…

Together with pharmacoresistant seizures, the quality of life of temporal lobe epilepsy (TLE)
patients is negatively impacted by behavioral comorbidities including but not limited to�…

Affective symptoms such as anxiety and depression are frequently observed in patients with
epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however�…

Patients with epilepsy are prone to cognitive decline, depression, anxiety and other
behavioral disorders. Cognitive comorbidities are particularly common and well�…

Here we describe a new non-human primate model of temporal lobe epilepsy (TLE) to better
investigate the cause/effect relationships of human TLE. Status epilepticus (SE) was induced�…

Many patients with epilepsy suffer from psychiatric comorbidities including depression,
anxiety, psychotic disorders, cognitive, and personality changes, but the mechanisms�…

Emotional distress is one of the most frequently reported seizure precipitants in epilepsy, but
little is known about its causes and processes. Interestingly, it is now accepted that�…

Psychiatric complaints afflict many patients with epilepsy, and these contribute significantly
to the impaired quality of life experienced by sufferers of this common group of neurological�…

Depression represents one of the most common comorbidities of temporal lobe epilepsy
(TLE), and has profound negative impact on the quality of life of patients with TLE. However�…

Systemic pilocarpine treatment is one of the most reliable means of inducing temporal lobe
epilepsy (TLE). However, the traditional pilocarpine injection protocol using mice was�…