Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model
Interictal spikes have been implicated in epileptogenesis and cognitive dysfunction in
epilepsy. Unfortunately, antiepileptic drugs have shown poor efficacy in suppressing�…
epilepsy. Unfortunately, antiepileptic drugs have shown poor efficacy in suppressing�…
Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus
Negatively charged sialic acid residues located close to pores of voltage-gated sodium
channels substantially influence their gating properties. The in vitro low Mg 2+ seizure�…
channels substantially influence their gating properties. The in vitro low Mg 2+ seizure�…
Neuraminidase activity in different regions of the seizing epileptic and non-epileptic brain
A Boyzo, J Ayala, R Guti�rrez, J Hern�ndez-R�- Brain research, 2003 - Elsevier
The sialic acid in the brain is split from sialoglucoconjugates by sialidases (neuraminidases,
EC 3.2. 1.18), and is postulated to act as an inhibitor of cellular adhesion and to play a role�…
EC 3.2. 1.18), and is postulated to act as an inhibitor of cellular adhesion and to play a role�…
Role of extracellular sialic acid in regulation of neuronal and network excitability in the rat hippocampus
The extracellular membrane surface contains a substantial amount of negatively charged
sialic acid residues. Some of the sialic acids are located close to the pore of voltage-gated�…
sialic acid residues. Some of the sialic acids are located close to the pore of voltage-gated�…
Interictal spikes and epileptogenesis
KJ Staley, FE Dudek�- Epilepsy currents, 2006 - journals.sagepub.com
Interictal spikes are widely accepted diagnostically as a sign of epilepsy, but reasons for the
presence of interictal activity in the epileptic brain are unknown. Interictal spikes are easily�…
presence of interictal activity in the epileptic brain are unknown. Interictal spikes are easily�…
The effect of neuraminidase blocker on gabazine-induced seizures in rat hippocampus
AV Savrasova, IV Lushnikova…�- …�of Physiology and�…, 2010 - dl.begellhouse.com
Concentration of neuraminidase (NEU), an enzyme which cleaves negatively charged sialic
acids from carbohydrate moieties of the cellular membrane, could vary depending on�…
acids from carbohydrate moieties of the cellular membrane, could vary depending on�…
Interictal spikes: harbingers or causes of epilepsy?
KJ Staley, A White, FE Dudek�- Neuroscience letters, 2011 - Elsevier
Interictal spikes are brief paroxysmal electrographic discharges observed between
spontaneous recurrent seizures in epileptic patients. The relationship between interictal�…
spontaneous recurrent seizures in epileptic patients. The relationship between interictal�…
Epilepsy in a dish: an in vitro model of epileptogenesis: epilepsy in a dish
M Wong�- Epilepsy currents, 2011 - journals.sagepub.com
Epilepsy in a Dish in vitro model system. Extracellular field potential recordings were made
from the CA3 region of organotypic hippocampal slice cultures between 7 and 30 days in�…
from the CA3 region of organotypic hippocampal slice cultures between 7 and 30 days in�…
Blockade of endogenous neuraminidase leads to an increase of neuronal excitability and activity‐dependent synaptogenesis in the rat hippocampus
Polysialic acids are widely distributed in neuronal tissue. Due to their position on
glycoproteins and gangliosides on the outer cell membranes and anionic nature, polysialic�…
glycoproteins and gangliosides on the outer cell membranes and anionic nature, polysialic�…
Interictal spikes: memories forsaken
CE Stafstrom�- Epilepsy currents, 2010 - journals.sagepub.com
Hippocampal Interictal Spikes Disrupt Cognition in Rats. Kleen JK, Scott RC, Holmes GL,
Lenck-Santini PP. Ann Neurol 2010; 67 (2): 250–257. OBJECTIVE: Cognitive impairment is�…
Lenck-Santini PP. Ann Neurol 2010; 67 (2): 250–257. OBJECTIVE: Cognitive impairment is�…