Gut microbiota bacterial depletions and altered metabolic activity at 3 months are implicated
in childhood atopy and asthma. We hypothesized that compositionally distinct human�…

Allergic diseases affect millions of people worldwide. An increase in their prevalence has
been associated with alterations in the gut microbiome, ie, the microorganisms and their�…

The composition of the human gut microbiome matures within the first years of life. It has
been hypothesized that microbial compositions in this period can cause immune�…

Gut microbiota dysbiosis and metabolic dysfunction in infancy precedes childhood atopy
and asthma development. Here we examined gut microbiota maturation over the first year of�…

Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural�…

Asthma is the most prevalent pediatric chronic disease and affects more than 300 million
people worldwide. Recent evidence in mice has identified a “critical window” early in life�…

Background The infant fecal microbiome is known to impact subsequent asthma risk, but the
environmental exposures impacting this association, the role of the maternal microbiome�…

Imbalance, or dysbiosis, of the gut microbiome of infants has been linked to an increased
risk of asthma and allergic diseases. Most studies to date have provided a wealth of data�…

The rapid rise in childhood allergies (atopy) in Westernized nations has implicated
associated environmental exposures and lifestyles as primary drivers of disease�…

Data from animal models suggest a role of early-life gut microbiota in lung immune
development, and in establishing susceptibility to respiratory infections and asthma in�…