The analysis highlighted an important role of chemokine signaling in colorectal cancer
progression and revealed previously undiscovered dynamic gene-expression patterns that�…

Next we reanalyzed a data set (~ 105 three-channel images) whose scale and complexity is
representative of highthroughput screens, which typically require dedicated image analysis�…

Despite advances in the detection and therapy of colorectal cancer (CRC) in recent years,
CRC has remained a major challenge in clinical practice. Although alternative methods for�…

To the Editor: Current state-of-the-art light-sheet microscopes rely on sophisticated control
software to perform the acquisition of gigabytes of image data per second over the course of�…

Intravital microscopy coupled with chronic animal window models has provided stunning
insight into tumor pathophysiology, including gene expression, angiogenesis, cell adhesion�…

To the editor: Adhesion complexes in cells growing on planar substrates have been studied
for over three decades. From these studies, several classes of adhesions have been�…

Current pathology workflow involves staining of thin tissue slices, which otherwise would be
transparent, followed by manual investigation under the microscope by a trained pathologist�…

To the Editor—Cutting-edge innovations in biological microscopy are increasingly blurring
the line between data acquisition and data analysis. Computational microscopy and�…

Histological examinations typically require the excision of tissue, followed by its fixation,
slicing, staining, mounting and imaging, with timeframes ranging from minutes to days. This�…

In 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet
microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging�…