Objectives. Topoisomerase II-alpha (T2a) is being actively investigated as a potential
predictive marker of response to anthracyclines in breast cancer (BC). Although the role of�…

Patients with advanced ovarian cancer (FIGO stage III) have a poor clinical prognosis.
However, these patients show distinct differences in their survival time, possibly due to�…

Objective. This study aimed to evaluate topoisomerase II compared to Ki-67 expression as a
marker for tumor behavior and for prognosis of patients with ovarian cancer. Methods. In�…

Background DNA topoisomerase II enzymes are key targets for the group of anti-tumour
agents known as topoisomerase inhibitors. In general, cell lines which express high levels of�…

Backgroud As magicians of the DNA world, topoisomerases resolve all of the topological
problems in relation to DNA during a variety of genetic processes. While the prognostic�…

OBJECTIVE: The aim of this study was to evaluate the expression of topoisomerase IIα
(TOP2A) in epithelial and stromal cells of ovarian cancer. METHODS: TOP2A expression�…

In the present study we examined prognostic value of immunohistochemical estimation of
topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with�…

To our knowledge, very few data about the role of Topoisomerase IIα (TOPO-IIα), an enzyme
involved in critical steps of tumour cell proliferation and chemoresistance are currently�…

Abstract Topoisomerase IIα (Top IIα) is a nuclear enzyme that plays a central role in DNA
metabolism, and is a molecular target for a variety of chemotherapeutic agents. Top IIα has�…

Topoisomerase IIα is not only a proliferation marker of tumor cells, but is also a target for
anthracycline-based chemotherapy. Both in vitro and in vivo studies have shown that there�…