Simple Summary Acquired resistance to molecularly targeted therapies remains a major
challenge in the treatment of cancer. It has been hypothesized that drug-tolerant (or�…

Simple Summary A major obstacle in the fight against cancer is the development of drug
resistance in response to therapy. Development of resistance can be facilitated by a small�…

A minor population of cancer cells may evade cell death from chemotherapy and targeted
therapy by entering a reversible slow proliferation state known as the drug tolerant persister�…

Although many drugs/treatments are now available for most diseases, too often, resistance
to these treatments impedes complete therapeutic success. Acquired resistance is a major�…

Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been�…

Cancer therapy has traditionally focused on eliminating fast-growing populations of cells.
Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can�…

Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The�…

One of the current stumbling blocks in our fight against cancer is the development of
acquired resistance to therapy, which is attributable to approximately 90% of cancer-related�…

Persistent cancer cells are the discrete and usually undetected cells that survive cancer drug
treatment and constitute a major cause of treatment failure. These cells are characterized by�…

Background Chemotherapy remains a major clinical option for the successful treatment of
cancer by eliminating fast-growing populations of cancer cells. However, drug resistance�…