The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their
ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that�…

The pro-survival protein Bcl-xL is critical for the resistance of tumour cells to DNA damage.
We have previously demonstrated, using a mouse cancer model, that oncogenic tyrosine�…

Bcl-xL is an antiapoptotic member of the Bcl-2 family, which inhibits apoptosis initiated by
various cellular stresses, and has a pivotal role in the survival of tumor cells. Researchers�…

Overexpression of Bcl-xL in multiple cancers correlates with resistance to chemotherapy and
radiation therapy, and provides a rationale for development of small-molecule Bcl-xL�…

The anthracyclin doxorubicin (DXR) is a major antitumor agent known to cause cellular
damage via a number of mechanisms including free radical formation and inhibition of�…

BH3 mimetics are small molecules designed or discovered to mimic the binding of BH3-only
proteins to the hydrophobic groove of antiapoptotic BCL2 proteins. The selectivity of these�…

The Bcl-2-family proteins have long been known for their role as key regulators of apoptosis.
Overexpression of various members of the family is associated with oncogenesis. Its�…

To investigate the exact biochemical functions by which Bcl-2 regulates apoptosis, we
established a stable human small cell lung carcinoma cell line, Ms-1, overexpressing wild�…

Impairment of apoptosis, the physiologic cell death process, is central to cancer
development and renders tumors refractory to cytotoxic therapy. Bcl-2, the oncoprotein�…

Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins,
drugs mimicking their natural antagonists, BH3-only proteins, might overcome�…