Initially discovered in the pituitary as stimulators of follicle stimulating hormone, activins are
homo-or heterodimers of inhibin subunits, which belong to the transforming growth factor-β�…

Objective The growth and differentiation factors activin and inhibin can affect tumour
formation and steroid production in the adrenal cortex. These factors bind to type I (Alk‐4)�…

Germ cell development is influenced by activin and inhibin, which are produced by Sertoli
cells. Activin also affects differentiation of mouse embryonal carcinoma cells, which, to a�…

The hypothesis that activin and inhibin are autocrine/paracrine mediators of ovarian
folliculogenesis has a solid basis. In mouse and rat models, granulosa cells (GC) of�…

The role of inhibin and activin in the initiation of follicular development, growth, and atresia
was examined. Human recombinant inhibin (1 μg) was unilaterally injected into the ovarian�…

During the human menstrual cycle, serum inhibin concentrations fluctuate in a cyclic fashion.
To examine the regulation of inhibin/activin βB subunit gene expression in ovarian�…

Introduction IN 1985 and 1986, inhibin and activin, respectively, were successfully isolated
from follicular fluid of the ovary (1, 2). Since then, our understanding of the important roles of�…

Activin receptors (ActRs) and gonadotropin receptor mRNA expression were investigated in
18 human ovarian epithelial neoplasms. Northern blot analysis showed the presence of 3.0�…

Objectives: Inhibins, dimeric peptide hormones composed of an α-subunit and 1 of 2
possible β subunits (βA or βB), exhibit substantial roles in human reproduction and in�…

Inhibin was first isolated in 1985. Major progress has been made in defining various aspects
of its structure and physiology, using a heterologous radioimmunoassay. Current research is�…