In this study, we have investigated the expression of inhibin subunits and activin receptors
(ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (α, βa�…

Introduction: Inhibins and activins are important regulators of the female reproductive
system. Recently, two novel inhibin subunits, named betaC (βC) and betaE (βE), have been�…

Activin and inhibin are structurally related dimeric glycoproteins belonging to the
transforming growth factor-β superfamily of proteins which are synthesized and secreted by�…

Objectives. To examine the possible localization and production of activin A in human
normal endometrium, endometrial hyperplasia, and adenocarcinoma tissues. Methods�…

Inhibins are dimeric glycoproteins, composed of an α-subunit and one of two possible β-
subunits (βA or βB), with substantial roles in human reproduction and in endocrine�…

Inhibins (INH) are dimeric glycoproteins composed of an alpha-subunit (INH-α) and one of
two possible beta-subunits (INH-βA or-βB), with substantial roles in human reproduction and�…

Background Inhibins and activins are important regulators of the female reproductive
system. Recently, two novel inhibin subunits, named betaC and betaE, have been identified�…

Malignant ovarian epithelial tumors have been shown to have decreased inhibin production
relative to activin production compared with normal ovarian surface epithelial (OSE) cells�…

Interest in inhibin as a marker of ovarian malignancy was stimulated by the description of
elevated immunoreactive inhibin levels in the sera of patients with granulosa cell tumours�…

Ovarian cancer strikes 1 in 70 women and is usually fatal. The frank mortality associated
with this disease is largely due to the lack of effective diagnostics and a poor understanding�…