PROBLEM: Elevated serum inhibin levels have been found in ovarian cancer patients;
however, the source of the elevated inhibin is uncertain. Previous studies of activin in human�…

Objectives. Inhibins and activins are related gonadal peptides with opposing biologic
actions on gonadotropin regulation, cell differentiation, and proliferation. The previous study�…

Objective: Our purpose was to examine the cellular localization of inhibin and activin
subunits in human epithelial ovarian tumors. Study Design: We examined the�…

Elevated serum immunoreactive inhibin concentrations have been reported in patients with
mucinous and granulosa cell tumors of the ovary. The present study aimed to determine�…

Objective Inhibin and activin are proteins produced by ovarian granulosa cells and testicular
Sertoli cells and are members of the transforming growth factor-beta superfamily. Since�…

Objective (s). Granulosa cell tumors (GCT) and mucinous cystadenocarcinoma of the ovary
are associated with elevated circulating levels of immunoreactive inhibin. Measurement of�…

Activin induces proliferation in epithelial ovarian carcinoma cell lines, whereas follistatin
(FS), an activin binding protein, inhibits this action. To test the hypothesis that activin�…

Both experimental and clinical studies suggest that inhibin plays a critical role in the
development of granulosa cell tumors (GCT), a subgroup of malignant ovarian tumors�…

Bioactive inhibins (α plus β subunit) and activins (two β subunits) are related nonsteroidal
dimeric proteins by virtue of their sharing two common β subunits. Initially, both inhibin and�…

Ovarian cancer is the most common fatal malignancy of the female reproductive tract and
frequently presents at an advanced stage. There is, thus, a great need for more sensitive�…