It is unknown whether ascorbate alone (vitamin C), its oxidized metabolite dehydroascorbic
acid alone, or both species are transported into human cells. This problem was addressed�…

Cellular ascorbic acid accumulation occursin vitro by two distinct mechanisms: transport of
ascorbate itself or transport and subsequent intracellular reduction of its oxidized product�…

L-ascorbic acid (ascorbate or vitamin C) is a required nutrient for humans. Absorption,
transport, and disposition of ingested ascorbate involve the following:(1) bioavailability and�…

As the initial step in the use of fibroblasts as a model system for 'in situ kinetics', ascorbic
acid (vitamin C) accumulation in normal human fibroblasts was investigated for the first time�…

The transport, accumulation, and distribution of ascorbic acid were investigated in isolated
human neutrophils utilizing a new ascorbic acid assay, which combined the techniques of�…

Many cell types transport vitamin C solely in its oxidized form, dehydroascorbic acid, through
facilitative glucose transporters. These cells accumulate large intracellular concentrations of�…

We performed a detailed kinetic analysis of the uptake of dehydroascorbic acid by HL-60
cells under experimental conditions that enabled the differentiation of dehydroascorbic acid�…

The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect
for the understanding of the roles played by this vitamin in pathophysiology. Considerable�…

Ascorbic acid (vitamin C) accumulation in activated human neutrophils is increased as much
as 10-fold above the mM concentrations present in normal neutrophils. Internal�…

Ascorbic acid (vitamin C) transport was investigated inhuman B lymphocytes. The vitamin
was transported by two components. The first was a high-affinity activity with an apparent Km�…