The role of mammary epithelial cell (MEC) NF-κB in tumor progression in vivo is unknown,
as murine NF-κB components and kinases either are required for murine survival or interfere�…

The transcription factor NF-κB is activated in a range of human cancers and is thought to
promote tumorigenesis, mainly due to its ability to protect transformed cells from apoptosis�…

The role of the canonical NF-κB pathway in mammary tumorigenesis was investigated using
a transgenic (TG) mouse expressing a dominant-negative inhibitor of κB (IκBα SR�…

The transcription factor nuclear factor kappa B (NF-κB) is activated in human breast cancer
tissues and cell lines. However, it is unclear whether NF-κB activation is a consequence of�…

Tumor-initiating cells (TICs) are a sub-population of cells that exhibit a robust ability to self-
renew and contribute to the formation of primary tumors, the relapse of previously treated�…

Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and
in treatment resistance and relapse. The molecular pathways required for their maintenance�…

NF-κB/Rel is a family of transcription factors which are expressed in all cells; however, in
most non-B cells, they are sequestered in the cytoplasm in inactive complexes with specific�…

Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated�…

The nuclear factor κB (NFκB) superfamily of eukaryotic transcription factors plays an
important role in carcinogenesis. NF-κB and its regulators are linked to various signal�…

The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of�…