Activin induces proliferation in epithelial ovarian carcinoma cell lines, whereas follistatin
(FS), an activin binding protein, inhibits this action. To test the hypothesis that activin�…

Although ovarian cancer is the most common gynecological malignancy with a relatively
poor 5-yr survival record, the mechanism (s) by which these tumors arise is not well�…

The activin/follistatin system is implicated in growth and differentiation of various cell types.
Follistatin (FS), through binding and neutralizing activin, plays a major role in the regulation�…

Objectives. Inhibins and activins are related gonadal peptides with opposing biologic
actions on gonadotropin regulation, cell differentiation, and proliferation. The previous study�…

Objectives. Activin A is a dimeric protein, composed of two β-A subunits, that belongs to the
TGF-β family of growth factors. Most primary epithelial ovarian tumors (96%) synthesize and�…

Inhibins and activins are growth factors belonging to the transforming growth factor-β) family
and are known to influence cell proliferation and differentiation. Because transforming�…

PROBLEM: Elevated serum inhibin levels have been found in ovarian cancer patients;
however, the source of the elevated inhibin is uncertain. Previous studies of activin in human�…

Objective: Our purpose was to examine the cellular localization of inhibin and activin
subunits in human epithelial ovarian tumors. Study Design: We examined the�…

Objective (s). Granulosa cell tumors (GCT) and mucinous cystadenocarcinoma of the ovary
are associated with elevated circulating levels of immunoreactive inhibin. Measurement of�…

Inhibin and activin are members of the transforming growth factor beta (TGFbeta) family of
cytokines produced by the gonads, with a recognised role in regulating pituitary FSH�…