Objective: To investigate the effect of nitric oxide (NO) on mitochondrial activity and its
relation with the apoptosis of human articular chondrocytes. Materials and methods�…

Background Nitric oxide (NO) is a messenger implicated in the destruction and inflammation
of joint tissues. Cartilage and synovial membrane from patients with rheumatoid arthritis�…

OBJECTIVE: Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In
osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study�…

Objective Osteoarthritis (OA) is a degenerative rheumatic disease that is associated with
extracellular matrix degradation and chondrocyte apoptosis in the articular cartilage. The�…

During inflammation, overproduction of nitric oxide (NO) can damage chondrocytes. In this
study, we separately evaluated the toxic effects of exogenous and endogenous NO on�…

In osteoarthritis (OA) a time or age dependent process leads to aberrant cartilage structure
which is characterized by reduced number of chondrocytes, loss of existing cartilage�…

Introduction The pathogenesis of osteoarthritis (OA) is characterized by the production of
high amounts of nitric oxide (NO), as a consequence of up-regulation of chondrocyte�…

Objective Biologic effects of nitric oxide (NO) have been shown to increase under hypoxic
conditions. Because the oxygen tension in joint cavities of patients with arthritis is fairly low�…

Objective Alterations in mitochondria play a key role in the pathogenesis of osteoarthritis
(OA). The role of inflammation in the progression of OA has also acquired important new�…

Previous studies identified that chondrocyte apoptosis serves an important role in
osteoarthritis (OA). However, the mechanisms of cartilage degeneration induced by�…