[HTML][HTML] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

MF Egan, M Kojima, JH Callicott, TE Goldberg…�- Cell, 2003 - cell.com
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and
hippocampal-dependent memory in cell models and in animals. We examined the effects of�…

Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance

AR Hariri, TE Goldberg, VS Mattay…�- Journal of�…, 2003 - Soc Neuroscience
BDNF plays a critical role in activity-dependent neuroplasticity underlying learning and
memory in the hippocampus. A frequent single nucleotide polymorphism in the targeting�…

The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus

I Ninan, KG Bath, K Dagar, R Perez-Castro…�- Journal of�…, 2010 - Soc Neuroscience
The Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene results in
a defect in regulated release of BDNF and affects episodic memory and affective behaviors�…

Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity

R Hashimoto, Y Moriguchi, F Yamashita, T Mori…�- Neuroscience�…, 2008 - Elsevier
Brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent
neuroplasticity underlying learning and memory in the hippocampus. Recent human studies�…

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met

T Mizui, Y Ishikawa, H Kumanogoh…�- Proceedings of the�…, 2015 - National Acad Sciences
Most growth factors are initially synthesized as precursor proteins and subsequently
processed into their mature form by proteolytic cleavage, resulting in simultaneous removal�…

BDNF and memory processing

P Bekinschtein, M Cammarota, JH Medina�- Neuropharmacology, 2014 - Elsevier
Brain-derived neurotrophic factor has emerged as one of the most important molecules
involved in memory. Its wide role in different types of memories that depend on different�…

Essential role of brain-derived neurotrophic factor in adult hippocampal function

LM Monteggia, M Barrot, CM Powell…�- Proceedings of the�…, 2004 - National Acad Sciences
Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function.
However, it has been difficult to discern its role in the adult brain in influencing complex�…

BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae

C Chiaruttini, M Sonego, G Baj, M Simonato…�- Molecular and Cellular�…, 2008 - Elsevier
Brain-derived neurotrophic factor (BDNF) may exert contrasting effects depending on its
different subcellular sites of action (soma, dendrites, axons). These contrasting effects may�…

The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

L Pezawas, BA Verchinski, VS Mattay…�- Journal of�…, 2004 - Soc Neuroscience
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts
variation in human memory, and is associated with several neurological and psychiatric�…

Endogenous BDNF is required for long-term memory formation in the rat parietal cortex

M Alonso, P Bekinschtein, M Cammarota…�- Learning &�…, 2005 - learnmem.cshlp.org
Information storage in the brain is a temporally graded process involving different memory
phases as well as different structures in the mammalian brain. Cortical plasticity seems to be�…