MRI biomarkers for post-traumatic epileptogenesis
R Immonen, I Kharatishvili, O Gr�hn…�- Journal of�…, 2013 - liebertpub.com
The present study tested a hypothesis that early identification of injury severity with
quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting�…
quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting�…
ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury
L Frey, A Lepkin, A Schickedanz, K Huber…�- Neurological�…, 2014 - Taylor & Francis
Objective: Post-traumatic epilepsy (PTE) is a serious complication of traumatic brain injury
(TBI). This study is designed to determine the feasibility of using multiparametric MRI�…
(TBI). This study is designed to determine the feasibility of using multiparametric MRI�…
Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
Severity of traumatic brain injury (TBI) positively correlates with the risk of post-traumatic
epilepsy (PTE). Studies on post-traumatic epileptogenesis would greatly benefit from�…
epilepsy (PTE). Studies on post-traumatic epileptogenesis would greatly benefit from�…
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
I Kharatishvili, R Immonen, O Gr�hn, A Pitk�nen�- Brain, 2007 - academic.oup.com
The need to use animal models to develop imaging markers that could be linked to
electrophysiological abnormalities in epilepsy and able to predict epileptogenicity in human�…
electrophysiological abnormalities in epilepsy and able to predict epileptogenicity in human�…
Early Increase in Cortical T2 Relaxation Is a Prognostic Biomarker for the Evolution of Severe Cortical Damage, but Not for Epileptogenesis, after Experimental�…
E Manninen, K Chary, N Lapinlampi…�- Journal of�…, 2020 - liebertpub.com
Prognostic biomarkers for post-injury outcome are necessary for the development of
neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We�…
neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We�…
Acute thalamic damage as a prognostic biomarker for post‐traumatic epileptogenesis
E Manninen, K Chary, N Lapinlampi, P Andrade…�- …, 2021 - Wiley Online Library
Objective To identify magnetic resonance imaging (MRI) biomarkers for post‐traumatic
epilepsy. Methods The EPITARGET (Targets and biomarkers for antiepileptogenesis�…
epilepsy. Methods The EPITARGET (Targets and biomarkers for antiepileptogenesis�…
Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis
R Immonen, G Smith, RD Brady, D Wright, L Johnston…�- Epilepsy research, 2019 - Elsevier
Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-
of-concept studies with limited animal numbers, and thus lack the statistical power for�…
of-concept studies with limited animal numbers, and thus lack the statistical power for�…
Early brain biomarkers of post-traumatic seizures: initial report of the multicentre epilepsy bioinformatics study for antiepileptogenic therapy (EpiBioS4Rx) prospective�…
ES Lutkenhoff, V Shrestha, JR Tejeda…�- Journal of Neurology�…, 2020 - jnnp.bmj.com
Background Traumatic brain injury (TBI) causes early seizures and is the leading cause of
post-traumatic epilepsy. We prospectively assessed structural imaging biomarkers�…
post-traumatic epilepsy. We prospectively assessed structural imaging biomarkers�…
[HTML][HTML] Acute hippocampal damage as a prognostic biomarker for cognitive decline but not for epileptogenesis after experimental traumatic brain injury
It is necessary to develop reliable biomarkers for epileptogenesis and cognitive impairment
after traumatic brain injury when searching for novel antiepileptogenic and cognition�…
after traumatic brain injury when searching for novel antiepileptogenic and cognition�…
Imaging biomarkers of posttraumatic epileptogenesis
Traumatic brain injury (TBI) affects 2.5 million people annually within the United States
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital�…
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital�…
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