MRI biomarkers for post-traumatic epileptogenesis

R Immonen, I Kharatishvili, O Gr�hn…�- Journal of�…, 2013 - liebertpub.com
The present study tested a hypothesis that early identification of injury severity with
quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting�…

ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury

L Frey, A Lepkin, A Schickedanz, K Huber…�- Neurological�…, 2014 - Taylor & Francis
Objective: Post-traumatic epilepsy (PTE) is a serious complication of traumatic brain injury
(TBI). This study is designed to determine the feasibility of using multiparametric MRI�…

Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat

I Kharatishvili, A Sierra, RJ Immonen, OHJ Gr�hn…�- Experimental�…, 2009 - Elsevier
Severity of traumatic brain injury (TBI) positively correlates with the risk of post-traumatic
epilepsy (PTE). Studies on post-traumatic epileptogenesis would greatly benefit from�…

Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis

I Kharatishvili, R Immonen, O Gr�hn, A Pitk�nen�- Brain, 2007 - academic.oup.com
The need to use animal models to develop imaging markers that could be linked to
electrophysiological abnormalities in epilepsy and able to predict epileptogenicity in human�…

Early Increase in Cortical T2 Relaxation Is a Prognostic Biomarker for the Evolution of Severe Cortical Damage, but Not for Epileptogenesis, after Experimental�…

E Manninen, K Chary, N Lapinlampi…�- Journal of�…, 2020 - liebertpub.com
Prognostic biomarkers for post-injury outcome are necessary for the development of
neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We�…

Acute thalamic damage as a prognostic biomarker for post‐traumatic epileptogenesis

E Manninen, K Chary, N Lapinlampi, P Andrade…�- …, 2021 - Wiley Online Library
Objective To identify magnetic resonance imaging (MRI) biomarkers for post‐traumatic
epilepsy. Methods The EPITARGET (Targets and biomarkers for antiepileptogenesis�…

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

R Immonen, G Smith, RD Brady, D Wright, L Johnston…�- Epilepsy research, 2019 - Elsevier
Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-
of-concept studies with limited animal numbers, and thus lack the statistical power for�…

Early brain biomarkers of post-traumatic seizures: initial report of the multicentre epilepsy bioinformatics study for antiepileptogenic therapy (EpiBioS4Rx) prospective�…

ES Lutkenhoff, V Shrestha, JR Tejeda…�- Journal of Neurology�…, 2020 - jnnp.bmj.com
Background Traumatic brain injury (TBI) causes early seizures and is the leading cause of
post-traumatic epilepsy. We prospectively assessed structural imaging biomarkers�…

[HTML][HTML] Acute hippocampal damage as a prognostic biomarker for cognitive decline but not for epileptogenesis after experimental traumatic brain injury

E Manninen, K Chary, R De Feo, E H�m�l�inen…�- Biomedicines, 2022 - mdpi.com
It is necessary to develop reliable biomarkers for epileptogenesis and cognitive impairment
after traumatic brain injury when searching for novel antiepileptogenic and cognition�…

Imaging biomarkers of posttraumatic epileptogenesis

R Garner, M La Rocca, P Vespa, N Jones, MM Monti…�- …, 2019 - Wiley Online Library
Traumatic brain injury (TBI) affects 2.5 million people annually within the United States
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital�…