Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific
tumour types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in�…

Ferroptosis, a new form of non-apoptotic, regulated cell death characterized by iron
dependency and lipid peroxidation, is involved in many pathological conditions such as�…

Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown.
We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules�…

Cell death is an essential feature of development in multicellular organisms, a critical driver
of degenerative diseases, and can be harnessed for treating some cancers. Understanding�…

Ferroptosis is a cell death process driven by damage to cell membranes and linked to
numerous human diseases. Ferroptosis is caused by loss of activity of the key enzyme that is�…

The system XC−/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls
ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling�…

Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed�…

Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of�…

Ferroptosis is a form of programmed cell death characterized by intracellular iron
accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4�…

Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid
peroxidation and metabolic constraints. Dependence on NADPH/H+, polyunsaturated fatty�…