The role of inflammation in epileptogenesis
One compelling challenge in the therapy of epilepsy is to develop anti-epileptogenic drugs
with an impact on the disease progression. The search for novel targets has focused�…
with an impact on the disease progression. The search for novel targets has focused�…
Epilepsy and brain inflammation
During the last decade, experimental research has demonstrated a prominent role of glial
cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and�…
cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and�…
Inflammation and epilepsy: preclinical findings and potential clinical translation
G Terrone, A Salamone…�- Current pharmaceutical�…, 2017 - ingentaconnect.com
Background: The lack of treatments which can prevent epilepsy development or improve
disease prognosis represents an unmet and urgent clinical need. The development of such�…
disease prognosis represents an unmet and urgent clinical need. The development of such�…
Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?
A Vezzani�- Expert opinion on drug safety, 2015 - Taylor & Francis
Introduction: In the epilepsy therapeutic arena, there is urgent need for developing novel
antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the�…
antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the�…
[HTML][HTML] Inflammatory and immune mechanisms underlying epileptogenesis and epilepsy: From pathogenesis to treatment target
I Mukhtar�- Seizure, 2020 - Elsevier
Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a�…
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a�…
Role of inflammatory mediators in the pathogenesis of epilepsy
T Shimada, T Takemiya, H Sugiura…�- Mediators of�…, 2014 - Wiley Online Library
Epilepsy is one of the most common chronic brain disorders worldwide, affecting 1% of
people across different ages and backgrounds. Epilepsy is defined as the sporadic�…
people across different ages and backgrounds. Epilepsy is defined as the sporadic�…
The role of inflammation in epilepsy
Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and�…
enduring predisposition to generate seizures. Despite progress in pharmacological and�…
Brain inflammation as a biomarker in epilepsy
A Vezzani, A Friedman�- Biomarkers in medicine, 2011 - Taylor & Francis
Experimental and clinical evidence have demonstrated the increased synthesis of specific
inflammatory mediators, and the upregulation of their cognate receptors in the chronic�…
inflammatory mediators, and the upregulation of their cognate receptors in the chronic�…
Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies
EA van Vliet, E Aronica, A Vezzani…�- Neuropathology and�…, 2018 - Wiley Online Library
Accumulating evidence indicates an important pathophysiological role of brain inflammation
in epilepsy. In this review, we will provide an update of specific inflammatory pathways that�…
in epilepsy. In this review, we will provide an update of specific inflammatory pathways that�…
[HTML][HTML] Cytokines and neurodegeneration in epileptogenesis
P Wolinski, D Ksiazek-Winiarek, A Glabinski�- Brain Sciences, 2022 - mdpi.com
Epilepsy is a common brain disorder characterized by a heterogenous etiology. Its main
features are recurrent seizures. Despite many clinical studies, about 30% of cases are�…
features are recurrent seizures. Despite many clinical studies, about 30% of cases are�…