The enzymatic hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone
and dehydroisoan-drosterone, respectively, was studied in cells that were derived from four�…

The activity of the two membrane-bound sulfatases, estrone and dehydroepiandrosterone
sulfatases, are reported in human breast carcinoma tissues. In 21 tested tumors (12 from�…

Characteristics and activities of estrone sulfate (E1S) and dehydroepiandrosterone sulfate
(DHAS) sulfatases were studied in epithelium and stroma of benign hyperplastic tissues�…

Steroid sulfatase activity was measured in 89 human samples, using dehydroepi-
androsterone sulfate (DHEAS) as substrate. The lowest activity was that of follicular fluid�…

Revised Manuscript Received March 13, 1995� abstract: Steroid sulfatases are responsible
for the hydrolysis of 3/3-hydroxy steroid sulfates, such as cholesterol and pregnenolone�…

Because of the evidence of adrenal steroid support of normal prostate growth and perhaps
in the exacerbation of prostatic carcinoma and in consideration of the large pool of such�…

Estrone sulfatase is an important mechanism of local synthesis of biologically active
estrogens in human breast cancer. The human placental microsome and breast carcinoma�…

It is generally accepted that progesterone and� 14-androstenedione serve as intermediates
in the biosynthesis of estrogens by the normal human ovary. This tissue, however, has also�…

Steroid sulfatase (STS) desulfates a number of 3β-hydroxysteroid sulfates, converting
inactive steroid hormone to the active form. We have established an enzyme-linked�…

The ability of human breast tumor preparations to hydrolyze DHEA, estrone, and
testosterone sulfates was studied. Of the 85 tumor preparations examined, 31 tumors�…