Caloric restriction (CR) reduces the pathological effects of aging and extends the lifespan in
many species, including nonhuman primates, although the effect on the brain is less well�…

Caloric restriction (CR) reduces the pathological effects of aging and extends the lifespan in
many species, including nonhuman primates, although the effect on the brain is less well�…

Background Brain iron accumulation is a feature of Alzheimer disease (AD) but whether a
chronic dietary iron overload contributes to AD induction is unknown. We previously showed�…

While nutritional and neurobehavioral problems are associated with both iron deficiency
during growth and overload in the elderly, the effect of iron loading in growing ages on�…

Age-related brain iron accumulation is linked with oxidative stress, neurodegeneration and
cognitive decline. Certain nutrients can reduce brain iron concentration in animal models�…

Dietary caloric restriction (CR) is the only intervention repeatedly demonstrated to retard the
onset and incidence of age-related diseases, maintain function, and extend both lifespan�…

Over the last decades, studies from our laboratory and other groups using animal models
have shown that iron overload, resulting in iron accumulation in the brain, produces�…

Rhesus macaques on a calorie restricted diet (CR) develop less age-related disease, have
virtually no indication of diabetes, are protected against sarcopenia, and potentially live�…

Brain iron accumulation is supposed to play a central role in neurodegeneration by inducing
oxidative stress. Currently it is unknown to which extent iron entering brain over lifetime�…

Preservation of brain integrity with age is highly associated with lifespan determination.
Caloric restriction (CR) has been shown to increase longevity and healthspan in various�…