Normal (nonneoplastic) human prostatic secretory epithelial cells do not express the bcl-2
protein. However, a recent immunohistochemical survey of neoplastic human prostate�…

The significance of apoptosis in relation to the development and progression of prostate
cancer remains largely undefined, bcl-2 is an oncogene that functions by overriding�…

The frequency of bcl-2 protein expression was evaluated using immunocytochemical
staining during the progression of human and rat prostate cancer from an androgen�…

Bcl-2 is an anti-apoptotic oncoprotein and its protein levels are inversely correlated with
prognosis in many cancers. However, the role of Bcl-2 in the progression of prostate cancer�…

The oncoprotein encoded by bc1-2 is unique because of its intracellular location (a
mitochondrial membrane protein) and apparent mode of action (suppression of apoptosis)�…

Proteins encoded by bcl-2 family genes are important regulators of programmed cell death
and apoptosis. Alterations in the expression of these apoptosis-regulating genes can�…

Prostate cancer progression and the development of androgen-independent prostate cancer
have been largely related to a number of genetic abnormality that affect not only the�…

Prostatic adenocarcinoma has a divergent response to androgen ablation and a varied long-
term prognosis. BCL-2 is a proto-oncogene that prevents programmed cell death. Since�…

In this study we evaluated the effect of over‐expression of the bcl‐2 gene, a potent apoptosis
suppressor, on radiation‐induced apoptotic cell death in 2 human prostate cancer cell lines�…

The clinical course of prostate cancer is highly variable and cannot satisfactorily be
predicted by histological criteria alone. To study the prognostic significance of Bcl-2 and p53�…