The direct involvement of melatonin in modulation of ovarian steroidogenesis, the high
levels of melatonin found in human follicular fluid, and the presence of melatonin binding�…

In this study, we have demonstrated that 2-[125I]-iodomelatonin binds specifically to rat
ovarian granulosa cell (GC) membranes with high affinity (KD= 83 pM; Bmax= 3.28 fmol/mg�…

We have shown that the melatonin receptor agonist, 2-[125I] iodomelatonin, binds to high-
affinity guanine nucleotide-sensitive sites on human granulosa (HG) cell membranes. In�…

This study investigated the receptor mechanism (s) by which the hormone melatonin directly
affects ovarian function. Expression of MT1 and MT2 melatonin receptor mRNA was�…

The pineal hormone melatonin participates in circadian, seasonal, and reproductive
physiology. The presence of melatonin binding sites in human brain and peripheral tissues�…

The mechanisms that mediate the various effects of melatonin in mammalian tissues are not
always known. Therefore, the aim of this study was to investigate whether MT1 and MT2�…

Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian
steroidogenesis and progesterone (P4) synthesis. Melatonin and its receptors are�…

Background Melatonin is associated with direct or indirect actions upon female reproductive
function. However, its effects on sex hormones and steroid receptors during ovulation are�…

The circadian timing of spontaneous human deliveries results in births occurring statistically
more often during the nocturnal phase of the 24-h cycle. The neuroendocrine mechanisms�…

Objective To test the hypothesis that melatonin modulates steroid synthesis in the human
ovary. Design Granulosa lutein cells obtained from in vitro fertilization cycles were cultured�…