Impairment of Multiple Interneurons in Dravet Mice where they exert powerful feed-forward
inhibition. Martinotti cells target the apical dendrites of layer V tufted pyramidal neurons and�…

Developmental and epileptic encephalopathies (DEEs) are neurological disorders generally
involving medically intractable seizures and a diverse array of comorbid neuropsychiatric�…

Dravet syndrome is a severe, childhood-onset epilepsy largely due to heterozygous loss-of-
function mutation of the gene SCN1A, which encodes the type 1 neuronal voltage-gated�…

Dravet Syndrome (DS) is a rare autosomic encephalopathy with epilepsy linked to Nav1. 1
channel mutations and defective GABAergic signaling. Effective therapies for this syndrome�…

Neurological and psychiatric syndromes often have multiple disease traits, yet it is unknown
how such multi-faceted deficits arise from single mutations. Haploinsufficiency of the voltage�…

Dravet syndrome is a developmental and epileptic encephalopathy characterized by
seizures, behavioral abnormalities, developmental deficits, and elevated risk of sudden�…

Dravet syndrome (DS) is a developmental epileptic encephalopathy mainly caused by
functional NaV1. 1 haploinsufficiency in inhibitory interneurons. Recently, a new conditional�…

Heterozygous loss-of-function mutations in the brain sodium channel NaV1. 1 cause Dravet
syndrome (DS), a pharmacoresistant infantile-onset epilepsy syndrome with comorbidities of�…

Dravet syndrome (DS) is a neurodevelopmental disorder defined by treatment-resistant
epilepsy, autism spectrum disorder, and sudden death, due to pathogenic variants in�…

VIP Interneuron Impairment Promotes In Vivo Circuit Dysfunction and Autism-Related
Behaviors in Dravet Syndrome Goff KM, Liebergall SR, Jiang E, Somarowthu A, Goldberg�…