Purpose: Patients with epilepsy have varying degrees of postictal impairment including
confusion and amnesia. This impairment adds substantially to the disease burden of�…

Patients with epilepsy are at substantial risk for memory impairment. Animal studies have
paralleled these clinical observations, demonstrating impaired hippocampal function as�…

Status epilepticus (SE) is a frequent neurological emergency associated with a significant
risk of morbidity in survivors. Impairment of hippocampal-specific memory is a common and�…

Repetitive one-per-day seizures induced in otherwise normal rats by the volatile convulsant
flurothyl decrease the accuracy of locating a hidden goal without changing the mean�…

Impaired Single Cell Firing and Long-term Potentiation Parallels Memory Impairment
Following Recurrent Seizures. Zhou JL, Shatskikh TN, Liu X, Holmes GL. Eur J Neurosci�…

Abstract See Lenck-Santini (doi: 10.1093/awx205) for a scientific commentary on this article.
Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution�…

Purpose: The interictal EEG spike (s) is the hallmark of the epileptic EEG. While focal
interictal spike (IS) have been associated with transitory cognitive impairment, with the type�…

In the hippocampus, pyramidal cells encode information in two major ways: rate coding and
temporal coding. Rate coding, in which information is coded through firing frequency, is�…

Previous studies suggest that spontaneous seizures in patients with temporal lobe epilepsy
might be preceded by increased action potential firing of hippocampal neurons. Preictal�…

Status epilepticus (SE) is often followed by severe cognitive impairment, including memory
impairment. Previous studies have shown that SE is associated with impairment of single�…