[HTML][HTML] Vertical Metabolome Transfer from Mother to Child: An Explainable Machine Learning Method for Detecting Metabolomic Heritability
Vertical transmission of metabolic constituents from mother to child contributes to the
manifestation of disease phenotypes in early life. This study probes the vertical transmission�…
manifestation of disease phenotypes in early life. This study probes the vertical transmission�…
[HTML][HTML] Intergenerational metabolomic analysis of mothers with a history of gestational diabetes mellitus and their offspring
R Ott, X Pawlow, A Wei�, A Hofelich, M Herbst…�- International Journal of�…, 2020 - mdpi.com
Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-
child transmission of adverse metabolic health. This study aimed to investigate whether�…
child transmission of adverse metabolic health. This study aimed to investigate whether�…
Molecular gatekeeper discovery: workflow for linking multiple exposure biomarkers to metabolomics
The exposome reflects multiple exposures across the life-course that can affect health.
Metabolomics can reveal the underlying molecular basis linking exposures to health�…
Metabolomics can reveal the underlying molecular basis linking exposures to health�…
[HTML][HTML] Using Mendelian randomisation to prioritise candidate maternal metabolic traits influencing offspring birthweight
CJS Barry, DA Lawlor, CY Shapland, E Sanderson…�- Metabolites, 2022 - mdpi.com
Marked physiological changes in pregnancy are essential to support foetal growth; however,
evidence on the role of specific maternal metabolic traits from human studies is limited. We�…
evidence on the role of specific maternal metabolic traits from human studies is limited. We�…
[HTML][HTML] A population-based resource for intergenerational metabolomics analyses in pregnant women and their children: The Generation R Study
Introduction Adverse exposures in early life may predispose children to cardio-metabolic
disease in later life. Metabolomics may serve as a valuable tool to disentangle the metabolic�…
disease in later life. Metabolomics may serve as a valuable tool to disentangle the metabolic�…
Genetics and not shared environment explains familial resemblance in adult metabolomics data
Metabolites are small molecules involved in cellular metabolism where they act as reaction
substrates or products. The term 'metabolomics' refers to the comprehensive study of these�…
substrates or products. The term 'metabolomics' refers to the comprehensive study of these�…
Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's
Even though the majority of population studies in environmental health focus on a single
factor, environmental exposure in the real world is a mixture of many chemicals. The concept�…
factor, environmental exposure in the real world is a mixture of many chemicals. The concept�…
Global metabolomic profiling reveals hepatic biosignatures that reflect the unique metabolic needs of late‐term mother and fetus
Objective Gestational disorders including preeclampsia, growth restriction and diabetes are
characterized, in part, by altered metabolic interactions between mother and fetus�…
characterized, in part, by altered metabolic interactions between mother and fetus�…
Associations of prenatal metabolomics profiles with early childhood growth trajectories and obesity risk in African Americans: the CANDLE study
Objective Prenatal metabolomics profiles, providing measures of in utero nutritional and
environmental exposures, may improve the prediction of childhood outcomes. We aimed to�…
environmental exposures, may improve the prediction of childhood outcomes. We aimed to�…
Prepregnant obesity of mothers in a multiethnic cohort is associated with cord blood metabolomic changes in offspring
RJ Schlueter, FM Al-Akwaa, PA Benny…�- Journal of proteome�…, 2020 - ACS Publications
Maternal obesity has become a growing global health concern that may predispose the
offspring to medical conditions later in life. However, the metabolic link between maternal�…
offspring to medical conditions later in life. However, the metabolic link between maternal�…