[HTML][HTML] Vertical Metabolome Transfer from Mother to Child: An Explainable Machine Learning Method for Detecting Metabolomic Heritability

M Lovrić, D Horner, L Chen, N Brustad…�- Metabolites, 2024 - mdpi.com
Vertical transmission of metabolic constituents from mother to child contributes to the
manifestation of disease phenotypes in early life. This study probes the vertical transmission�…

[HTML][HTML] Intergenerational metabolomic analysis of mothers with a history of gestational diabetes mellitus and their offspring

R Ott, X Pawlow, A Wei�, A Hofelich, M Herbst…�- International Journal of�…, 2020 - mdpi.com
Shared metabolomic patterns at delivery have been suggested to underlie the mother-to-
child transmission of adverse metabolic health. This study aimed to investigate whether�…

Molecular gatekeeper discovery: workflow for linking multiple exposure biomarkers to metabolomics

M Yu, SL Teitelbaum, G Dolios, LHT Dang…�- …�science & technology, 2022 - ACS Publications
The exposome reflects multiple exposures across the life-course that can affect health.
Metabolomics can reveal the underlying molecular basis linking exposures to health�…

[HTML][HTML] Using Mendelian randomisation to prioritise candidate maternal metabolic traits influencing offspring birthweight

CJS Barry, DA Lawlor, CY Shapland, E Sanderson…�- Metabolites, 2022 - mdpi.com
Marked physiological changes in pregnancy are essential to support foetal growth; however,
evidence on the role of specific maternal metabolic traits from human studies is limited. We�…

[HTML][HTML] A population-based resource for intergenerational metabolomics analyses in pregnant women and their children: The Generation R Study

E Voerman, VWV Jaddoe, O Uhl, E Shokry, J Horak…�- Metabolomics, 2020 - Springer
Introduction Adverse exposures in early life may predispose children to cardio-metabolic
disease in later life. Metabolomics may serve as a valuable tool to disentangle the metabolic�…

Genetics and not shared environment explains familial resemblance in adult metabolomics data

R Pool, FA Hagenbeek, AM Hendriks…�- Twin research and�…, 2020 - cambridge.org
Metabolites are small molecules involved in cellular metabolism where they act as reaction
substrates or products. The term 'metabolomics' refers to the comprehensive study of these�…

Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's

S Li, P Cirillo, X Hu, VL Tran, N Krigbaum, S Yu…�- Reproductive�…, 2020 - Elsevier
Even though the majority of population studies in environmental health focus on a single
factor, environmental exposure in the real world is a mixture of many chemicals. The concept�…

Global metabolomic profiling reveals hepatic biosignatures that reflect the unique metabolic needs of late‐term mother and fetus

N Saini, M Virdee, KK Helfrich, STC Kwan, SM Smith�- Metabolomics, 2021 - Springer
Objective Gestational disorders including preeclampsia, growth restriction and diabetes are
characterized, in part, by altered metabolic interactions between mother and fetus�…

Associations of prenatal metabolomics profiles with early childhood growth trajectories and obesity risk in African Americans: the CANDLE study

Q Zhao, Z Hu, M Kocak, J Liu, JH Fowke…�- International Journal of�…, 2021 - nature.com
Objective Prenatal metabolomics profiles, providing measures of in utero nutritional and
environmental exposures, may improve the prediction of childhood outcomes. We aimed to�…

Prepregnant obesity of mothers in a multiethnic cohort is associated with cord blood metabolomic changes in offspring

RJ Schlueter, FM Al-Akwaa, PA Benny…�- Journal of proteome�…, 2020 - ACS Publications
Maternal obesity has become a growing global health concern that may predispose the
offspring to medical conditions later in life. However, the metabolic link between maternal�…