Global ischemia in childhood often leads to poor neurologic outcomes, including learning
and memory deficits. Using our novel model of childhood cardiac arrest/cardiopulmonary�…

Traumatic brain injury (TBI) is the leading cause of death and disability in children. Indeed,
the acute mechanical injury often evolves to a chronic brain disorder with long-term�…

Traumatic brain injury (TBI) is a leading cause of pediatric morbidity and mortality. Recent
studies suggest that children and adolescents have worse post-TBI outcomes and take�…

Brain ischemia affects all ages, from neonates to the elderly population, and is a leading
cause of mortality and morbidity. Multiple preclinical rodent models involving different ages�…

1750 Arterioscler Thromb Vasc Biol August 2012 schematic outline in Figure). If this concept
also applies to humans, decreased activity of the Bdnf-TrkB axis in humans with�…

Background: Despite treatment with therapeutic hypothermia (TH), infants who survive
hypoxic ischemic (HI) encephalopathy (HIE) have persistent neurological abnormalities at�…

Preclinical stroke research has introduced a number of potential interventions that can be
utilized to enhance recovery after stroke (Lo and Rosenberg, 2009). Many of these potential�…

Ischemic preconditioning (IPC) via protein kinase C epsilon (PKCε) activation induces
neuroprotection against lethal ischemia. Brain-derived neurotrophic factor (BDNF) is a pro�…

Neuroprotective strategies aimed to pharmacologically treat stroke, a prominent cause of
death, disability, and dementia, have remained elusive. A promising approach is restriction�…

Aim Retrospective studies suggest that mild traumatic brain injury (mTBI) in pediatric
patients may lead to an increased risk of cardiac events. However, the exact functional and�…