The tumor microenvironment is a complex ecology of cells that evolves with and provides
support to tumor cells during the transition to malignancy. Among the innate and adaptive�…

The number and phenotype of macrophages are closely related to tumor growth and
prognosis. Macrophages are recruited to (and polarized at) the tumor site thereby promoting�…

Macrophages are one of the most abundant immune cells in the tumour microenvironment of
solid tumours and their presence correlates with reduced survival in most cancers�…

The tumor microenvironment is overwhelmingly dictated by macrophages, intimately
affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis�…

Tumor-associated macrophages are one of the major constituents of tumor stroma in many
solid tumors and there is compelling preclinical and clinical evidence that macrophages�…

Macrophages, which have functions of engulfing and digesting foreign substances, can
clear away harmful matter, including cellular debris and tumor cells. Based on the condition�…

Macrophages are ubiquitous cells physiologically involved in a variety of processes
including pathogen destruction, inflammation, tissue repair and remodeling. They have a�…

Macrophages constitute a dominant fraction of the population of immune cells that infiltrate
developing tumors. Recruited by tumor-derived signals, tumor-infiltrating macrophages are�…

There is persuasive clinical and experimental evidence that macrophages promote cancer
initiation and malignant progression. During tumor initiation, they create an inflammatory�…

Macrophages are widely distributed innate immune cells that play indispensable roles in the
innate and adaptive immune response to pathogens and in‐tissue homeostasis�…