Human DNA polymerase η (HsPolη) plays an important role in translesion synthesis (TLS),
which allows for replication past DNA damage such as UV‐induced cis-syn cyclobutane�…

DNA polymerases are evolved to extend the 3′-OH of a growing primer annealed to a
template DNA substrate. Since replicative DNA polymerases have a limited role while�…

Y-family DNA polymerases (pols) consist of six phylogenetically separate subfamilies; two
UmuC (polV) branches, DinB (pol IV, Dpo4, polκ), Rad30A/POLH (polη), and Rad30B/POLI�…

To assess how evolution might have biochemically shaped DNA polymerase η (Polη) in
plants, we expressed in Escherichia coli proteins from Arabidopsis thaliana (At), humans�…

For many years, Taq polymerase has served as the stalwart enzyme in the PCR
amplification of DNA. However, a major limitation of Taq is its inability to amplify damaged�…

Pre-steady-state kinetic studies on Y-family DNA polymerase η (Polη) have suggested that
the polymerase undergoes a rate-limiting conformational change step before the phosphoryl�…

Y‐family DNA polymerases can replicate past a variety of damaged bases in vitro but, with
the exception of DNA polymerase η (polη), which is defective in xeroderma pigmentosum�…

DNA polymerase η (polη) is a Y-family translesion synthesis polymerase that plays a key
role in the cellular tolerance toward UV irradiation-induced DNA damage. Here, we�…

Abstract Family A DNA polymerases (PolAs) form an important and well-studied class of
extant polymerases participating in DNA replication and repair. Nonetheless, despite the�…

In translesion synthesis (TLS), specialized DNA polymerases (pols) facilitate progression of
replication forks stalled by DNA damage. Although multiple TLS pols have been identified in�…