To increase the normal rate of adult neurogenesis, the authors used the amygdala kindling
model of TLE, where electrical stimulations (99 stimulation sessions at a regimen of 3 per�…

Purpose: Proliferation of neural precursors adjacent to the granule cell layer of the dentate
gyrus has been identified in previous epilepsy models. Convincingly demonstrating that�…

Kindling, a form of neuronal plasticity produced by repeated low intensity electrical brain
stimulation, leads to epileptic seizures. To address possible causes of this phenomenon, we�…

Epileptic seizures increase the birth of new neurons in the adult hippocampus. Although the
consequences of aberrant neurogenesis on behavior are not fully understood, one�…

Several factors, including epileptic seizures, can strongly stimulate ongoing neurogenesis in
the adult hippocampus. Although adult‐born granule cells generated after seizure activity�…

Multiple studies have highlighted how seizures induce different molecular, cellular, and
physiologic consequences in an immature brain as compared to a mature brain. In keeping�…

Do early seizures beget seizures later in life? Clinical data and experimental observations
seem to answer that question differently, with a no and a yes, respectively, which may stem�…

In the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function
of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent�…

It is well established that seizures increase adult neurogenesis in the subventricular and
subgranular zones, the most neurogenic regions of the adult rodent and apparently human�…

Both clinical and laboratory studies demonstrate that seizures early in life can result in
permanent behavioral abnormalities and enhance epileptogenicity. In experimental rodent�…