Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse
species; however, its effect on resistance to illness and mortality in primates has not been�…

Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-
related disorders in most species but its impact in nonhuman primates has been�…

Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported
as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is�…

Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-
associated disorders in short-lived species, from unicellular organisms to laboratory mice�…

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22�…

Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends
mean and maximal life span in short‐lived mammalian species. This nutritional intervention�…

Calorie restriction (CR) is widely known for its effects on life span, physiological aging and
age-related disease in laboratory rats and mice. Emerging data from CR studies in rhesus�…

Calorie restriction (CR) extends lifespan and reduces the incidence and age of onset of age-
related disease in several animal models. To determine if this nutritional intervention has�…

Calorie Restriction (CR) without malnutrition slows aging and increases average and
maximal lifespan in simple model organisms and rodents. In rhesus monkeys long-term CR�…

In the 75 years since the seminal observation of Clive McCay that restriction of calorie intake
extends the lifespan of rats, a great deal has been learned about the effects of calorie�…