Sustained exposure to various psychological stressors can exacerbate neuropsychiatric
disorders, including drug addiction. Addiction is a chronic brain disease in which individuals�…

Rationale: The notion that stress leads to drug abuse in vulnerable individuals and relapse
in addicts is not new. Most major theories of addiction postulate that stress plays an�…

Stress is one of the most commonly reported precipitants of drug use and is considered the
number one cause of relapse to drug abuse. For the past several decades, there have been�…

ABSTRACT A challenging question that continues unanswered in the field of addiction is
why some individuals are more vulnerable to substance use disorders than others�…

The ability of stressful life events to trigger drug use is particularly problematic for the
management of cocaine addiction due to the unpredictable and often uncontrollable nature�…

Stress is a well‐known risk factor in the development of addiction and in addiction relapse
vulnerability. A series of population‐based and epidemiological studies have identified�…

Background The high prevalence and burden to society of drug abuse and addiction is
undisputed. However, its conceptualisation as a brain disease is controversial, and�…

Addition is a chronic relapsing illness affected by multiple social, individual and biological
factors that significantly impact course and recovery of the illness. Stress interacts with these�…

A number of studies have assessed the effects of psychoactive drugs on stress biology, the
neuroadaptations resulting from chronic drug use on stress biology, and their effects on�…

This article will review data obtained from both clinical and preclinical investigations
demonstrating that exposure to stress has a significant impact on drug addiction. The�…