Polyploid somatic cells have 'programmed'roles in normal development and stress
responses. Transient polyploidy states have been observed in several tumor types at early�…

Polyploidy, a state of increased number of chromosomes, occurs often in plants and less
frequently in animals. Polyploidization is recognized as a part of a developmental program�…

Cancer cells can undergo stress-induced premature senescence, which is considered to be
a desirable outcome of anticancer treatment. However, the escape from senescence and�…

In the last decade, the concept of “cancer stem cells” has emerged, recognised by the fact
that only a small fraction of tumour cells appears to retain the stem cell properties of self�…

Tetraploidy, a condition in which a cell has four homologous sets of chromosomes, is often
seen as a natural physiological condition but is also frequently seen in pathophysiological�…

In spite of significant advancements of therapies for initial eradication of cancers, tumor
relapse remains a major challenge. It is for a long time known that polyploid malignant cells�…

Metastatic cancer is rarely cured by current DNA damaging treatments, apparently due to the
development of resistance. However, recent data indicates that tumour cells can elicit the�…

Ploidy increase has been shown to occur in different type of tumors and participate in tumor
initiation and resistance to the treatment. Polyploid giant cancer cells (PGCCs) are cells with�…

Unusually large cancer cells with abnormal nuclei have been documented in the cancer
literature since 1858. For more than 100 years, they have been generally disregarded as�…

Cell senescence from exhausted cell expansions to cells with short, dysfunctional telomeres
is considered to be a non-replicative, irreversible state with possibility in tumor therapy. This�…