Haploinsufficiency of the voltage-gated sodium channel NaV1. 1 causes Dravet syndrome,
an intractable developmental epilepsy syndrome with seizure onset in the first year of life�…

Dravet syndrome is a severe, childhood-onset epilepsy largely due to heterozygous loss-of-
function mutation of the gene SCN1A, which encodes the type 1 neuronal voltage-gated�…

Heterozygous loss-of-function mutations in the brain sodium channel NaV1. 1 cause Dravet
syndrome (DS), a pharmacoresistant infantile-onset epilepsy syndrome with comorbidities of�…

Neurological and psychiatric syndromes often have multiple disease traits, yet it is unknown
how such multi-faceted deficits arise from single mutations. Haploinsufficiency of the voltage�…

Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy, intellectual
disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the�…

Voltage-gated sodium channels initiate action potentials (APs) in brain neurons, and sodium
channel blockers are used to treat epilepsy. Heterozygous loss-of-function mutations in Na V�…

Dominant loss-of-function mutations in voltage-gated sodium channel Na V 1.1 cause
Dravet Syndrome, an intractable childhood-onset epilepsy. Na V 1.1+/− Dravet Syndrome�…

Dravet syndrome is a severe epileptic encephalopathy mainly caused by heterozygous
mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1. 1. We�…

Mutations in voltage‐gated sodium channels are associated with epilepsy syndromes with a
wide range of severity. Complete loss of function in the Nav1. 1 channel encoded by the�…

Dravet syndrome (Dravet) is a rare, severe childhood-onset epilepsy, caused by
heterozygous de novo mutations in the SCN1A gene, encoding for the alpha subunit of the�…