[HTML][HTML] Gene expression and immune infiltration in melanoma patients with different mutation burden

L Wang, F Chen, R Liu, L Shi, G Zhao, Z Yan�- BMC cancer, 2021 - Springer
… Tumor mutation burden refers to the frequency of mutationsexpression with high TMB had
the most significant benefits, however, patients with elevated PD-L1 protein expression levels

…�mutation burden in non–small cell lung cancers with increased immune infiltration and improved clinical outcomes of PD-L1 blockade across PD-L1 expression levels

B Ricciuti, X Wang, JV Alessi, H Rizvi…�- JAMA�…, 2022 - jamanetwork.com
mutations) was considered as the root, splitting patients into two groups. For the TMB high
group, the PD-L1 expression levels … for the TMB low group, the PD-L1 expression levels were …

[HTML][HTML] Correlate tumor mutation burden with immune signatures in human cancers

X Wang, M Li�- BMC immunology, 2019 - Springer
mutation load may inhibit immune cell infiltration in LIHC. Furthermore, we found 12 cancer
types in which the expression levels … cancer type in which the expression levels of this gene-…

[PDF][PDF] Tumor mutation burden: is it ready for the clinic?

Y Goto�- Journal of Clinical Oncology, 2018 - researchgate.net
… The primary end point was efficacy in patients with a PD-L1 expression level of 5% or more.
… -L1 expression level of patients. However, an exploratory analysis of tumor mutation burden (…

[HTML][HTML] PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers

M Yarchoan, LA Albacker, AC Hopkins, M Montesion…�- JCI insight, 2019 - ncbi.nlm.nih.gov
… To further investigate the relationship between viral antigen status and PD-L1 expression at
the level of individual tumor specimens, we looked for the presence of HPV, EBV, Merkel cell …

Exploration of gene expression profiles and immune microenvironment between high and low tumor mutation burden groups in prostate cancer

C Luo, J Chen, L Chen�- International Immunopharmacology, 2020 - Elsevier
… As presented, patients with higher expression levels of these genes had worse BCR-free
survival. The information of these six genes in high and low TMB groups was listed in Table 1. …

[HTML][HTML] Tumor mutation burden: from comprehensive mutational screening to the clinic

F Galuppini, CA Dal Pozzo, J Deckert, F Loupakis…�- Cancer cell�…, 2019 - Springer
… biomarker, irrespective of tumor PD-L1 expression level. The value of TMB assessment was
… TMB, irrespective of PD-L1 expression level and other investigated clinical and pathological …

[HTML][HTML] Correlation of PD-L1 expression with tumor mutation burden and gene signatures for prognosis in early-stage squamous cell lung carcinoma

H Yu, Z Chen, KV Ballman, MA Watson…�- Journal of Thoracic�…, 2019 - Elsevier
… In this study, we evaluated PD-L1 protein expression, tumor mutation burden, and expression
… In this study, we evaluated PD-L1 protein expression level in 255 early-stage SqCLCs by …

Prediction of tumor mutation burden in breast cancer based on the expression of ER, PR, HER-2, and Ki-67

J Xu, X Guo, M Jing, T Sun�- OncoTargets and therapy, 2018 - Taylor & Francis
… Frequencies of somatic mutations or tumor mutation burden (TMB) were associated with …
This study aimed to predict the level of TMB in patients with breast cancer by the expression of …

[HTML][HTML] Methods of measurement for tumor mutational burden in tumor tissue

B Mel�ndez, C Van Campenhout, S Rorive…�- …�lung cancer research, 2018 - ncbi.nlm.nih.gov
expression levels that complicates its evaluation; (II) it is a heterogeneous marker, with
intratumoral and temporal variation of expression… the mutational load or tumor mutational burden (…