[HTML][HTML] Gene expression and immune infiltration in melanoma patients with different mutation burden
L Wang, F Chen, R Liu, L Shi, G Zhao, Z Yan�- BMC cancer, 2021 - Springer
… Tumor mutation burden refers to the frequency of mutations … expression with high TMB had
the most significant benefits, however, patients with elevated PD-L1 protein expression levels …
the most significant benefits, however, patients with elevated PD-L1 protein expression levels …
…�mutation burden in non–small cell lung cancers with increased immune infiltration and improved clinical outcomes of PD-L1 blockade across PD-L1 expression levels
B Ricciuti, X Wang, JV Alessi, H Rizvi…�- JAMA�…, 2022 - jamanetwork.com
… mutations) was considered as the root, splitting patients into two groups. For the TMB high
group, the PD-L1 expression levels … for the TMB low group, the PD-L1 expression levels were …
group, the PD-L1 expression levels … for the TMB low group, the PD-L1 expression levels were …
[HTML][HTML] Correlate tumor mutation burden with immune signatures in human cancers
X Wang, M Li�- BMC immunology, 2019 - Springer
… mutation load may inhibit immune cell infiltration in LIHC. Furthermore, we found 12 cancer
types in which the expression levels … cancer type in which the expression levels of this gene-…
types in which the expression levels … cancer type in which the expression levels of this gene-…
[PDF][PDF] Tumor mutation burden: is it ready for the clinic?
Y Goto�- Journal of Clinical Oncology, 2018 - researchgate.net
… The primary end point was efficacy in patients with a PD-L1 expression level of 5% or more.
… -L1 expression level of patients. However, an exploratory analysis of tumor mutation burden (…
… -L1 expression level of patients. However, an exploratory analysis of tumor mutation burden (…
[HTML][HTML] PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers
M Yarchoan, LA Albacker, AC Hopkins, M Montesion…�- JCI insight, 2019 - ncbi.nlm.nih.gov
… To further investigate the relationship between viral antigen status and PD-L1 expression at
the level of individual tumor specimens, we looked for the presence of HPV, EBV, Merkel cell …
the level of individual tumor specimens, we looked for the presence of HPV, EBV, Merkel cell …
Exploration of gene expression profiles and immune microenvironment between high and low tumor mutation burden groups in prostate cancer
C Luo, J Chen, L Chen�- International Immunopharmacology, 2020 - Elsevier
… As presented, patients with higher expression levels of these genes had worse BCR-free
survival. The information of these six genes in high and low TMB groups was listed in Table 1. …
survival. The information of these six genes in high and low TMB groups was listed in Table 1. …
[HTML][HTML] Tumor mutation burden: from comprehensive mutational screening to the clinic
F Galuppini, CA Dal Pozzo, J Deckert, F Loupakis…�- Cancer cell�…, 2019 - Springer
… biomarker, irrespective of tumor PD-L1 expression level. The value of TMB assessment was
… TMB, irrespective of PD-L1 expression level and other investigated clinical and pathological …
… TMB, irrespective of PD-L1 expression level and other investigated clinical and pathological …
[HTML][HTML] Correlation of PD-L1 expression with tumor mutation burden and gene signatures for prognosis in early-stage squamous cell lung carcinoma
… In this study, we evaluated PD-L1 protein expression, tumor mutation burden, and expression
… In this study, we evaluated PD-L1 protein expression level in 255 early-stage SqCLCs by …
… In this study, we evaluated PD-L1 protein expression level in 255 early-stage SqCLCs by …
Prediction of tumor mutation burden in breast cancer based on the expression of ER, PR, HER-2, and Ki-67
J Xu, X Guo, M Jing, T Sun�- OncoTargets and therapy, 2018 - Taylor & Francis
… Frequencies of somatic mutations or tumor mutation burden (TMB) were associated with …
This study aimed to predict the level of TMB in patients with breast cancer by the expression of …
This study aimed to predict the level of TMB in patients with breast cancer by the expression of …
[HTML][HTML] Methods of measurement for tumor mutational burden in tumor tissue
B Mel�ndez, C Van Campenhout, S Rorive…�- …�lung cancer research, 2018 - ncbi.nlm.nih.gov
… expression levels that complicates its evaluation; (II) it is a heterogeneous marker, with
intratumoral and temporal variation of expression… the mutational load or tumor mutational burden (…
intratumoral and temporal variation of expression… the mutational load or tumor mutational burden (…